- in pregnant and breastfeeding women,
- under stress,
- in smokers, people who abuse alcohol,
- when using contraceptive pills, tetracyclines, barbiturates, corticosteroids,
- in city dwellers (due to omnipresent pollutants and toxins),
- during febrile states, infectious diseases, peptic ulcer disease,
- with regular intake of acetylsalicylic acid or other salicylates,
- in the elderly, surgical patients, people with tissue injuries,
- in people leading very intensive lifestyle.
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